What should you do when exposed to whooping cough (pertussis)?

I can recall when I was pregnant with our third child, my husband had whooping cough. Oh my…. what a doozy that was for him. He took antibiotics appropriately and STILL whooped for 6 months (while the cilia in his lungs was regrowing).

Consider getting a Tdap booster. (The T is tetanus, and the P is pertussis/whooping cough.) This is suggested once as an adult, for pregnant women in the third trimester of every pregnancy, or for those who have exposure to infants (like new grandparents) . You can also opt to get a Tdap every 10 years instead of a tetanus booster every 10 years.

Consistent with CDC guidance, most asymptomatic patients without prolonged close contact to a known pertussis case should NOT be tested or treated with antibiotics (e.g., azithromycin).

Asymptomatic Patients (in the setting of increased incidence and widespread community transmission)

  • Pertussis lab testing is not recommended
  • Antibiotic treatment or prophylaxis is indicated only in select situations, including:
    • Household or prolonged close contact with a confirmed case
    • High-risk individuals or those caring for them

Post-exposure prophylaxis is recommended for:

  • All household contacts of a person with confirmed pertussis, regardless of vaccination history
    • High-risk persons:
      • Infants (particularly those ≤12 months)
      • Hospitalized neonates and newborn infants
      • Women in the third trimester of pregnancy
      • Immunocompromised individuals
      • Patients with chronic respiratory conditions or other chronic health conditions that may increase pertussis-related morbidity
    • Persons who have or anticipate having close contact with high-risk individuals, particularly:
      • Those in contact with infants aged ≤12 months
      • Healthcare personnel in contact with hospitalized neonates, newborn infants, or patients with chronic respiratory conditions
    • Other healthcare personnel and close contacts can either receive postexposure prophylaxis or be carefully monitored for 21 days after exposure

Symptomatic Patients

  • Suspect pertussis in patients with a persistent, paroxysmal cough, often with a characteristic “whoop”
  • Patients with symptoms consistent with pertussis, and their close contacts, may be treated empirically with azithromycin without testing
  • Symptomatic patients should:
    • Isolate for 5 days after starting antibiotics
    • May return to school or work after 5 days (cough may persist for weeks)
  • Cough suppressants have limited effectiveness
  • Healthcare precautions for suspected and confirmed cases is droplet + standard precautions for the same duration.
  • Provide a regular ear-loop mask for the patient to wear

Additional Notes

  • Prior Tdap vaccination reduces disease severity but does not eliminate transmission or prophylaxis considerations
  • Antibiotics are not recommended after 21 days of cough, except for infants and pregnant patients in the 3rd trimester (up to 6 weeks)

I hope this helps.

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About drlesliegreenberg

I have been practicing as a family physician for over 20 years--as both an educator of physicians and clinician. From infancy to the elderly, I perform obstetrics and general medicine. I love my career and am passionate about my field of knowledge and my patients. Follow me on Facebook at Leslie Md Greenberg Medical Disclaimer The content of this website is provided for general informational purposes only and is not intended as, nor should it be considered a substitute for, professional medical advice. Do not use the information on this website for diagnosing or treating any medical or health condition. If you have or suspect you have a medical problem, promptly contact your professional healthcare provider.
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