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Proton pump weaning…  Many patients are on PPIs (like omeprazole) for gastroesophageal reflux disease.  It is thought that PPIs should only be used on a short-term basis for conditions like reflux or erosive esophagitis.

Consider stopping the PPI medication and instead take an over-the-counter H2-blocker (like Zantac or Pepcid).   Also, do “behavioral modification” like avoid food triggers (spicy or acidic foods, tobacco, alcohol, mint), eat smaller meals, and do not lie down within 3 hours of eating.

If you are unable to wean off of PPIs, then you should ask your doctor for ambulatory esophageal pH and impedance monitoring.  This will help discern if you have a functional syndrome or reflux.  Lifelong PPI treatment should not be done until this testing is done according to the “new best practices statement.”

I hope this helps.