Probably not. Here’s why…
There was a 2010 study that showed that Tylenol given before vaccines can actually BLUNT the immune response to the given vaccine. The CDC has since released a statement that there are basically no good studies supporting the use of Tylenol as pretreatment. Some parents think that the Tylenol beforehand will make the poke hurt less. I doubt this is a significant savings in pain and may decrease the ability for the body to respond to the vaccines. If a fever occurs due to the vaccine, then Tylenol may be given, but in many cases should not be needed. As a mom, I think that a hug and kiss do more to alleviate the “pinch” of a shot.
Of note, most patients have a fever on day 5 after their MMR vaccine. This is the measles, mumps, rubella vaccine that is given routinely at the well-child checks at 1 year and 4-5 years.
Hope this helps.